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Targeting XBP-1 as a novel anti-cancer strategy
Albert C Koong1, Vibha Chauhan, Lorenzo Romero-Ramirez
1Stanford University, Department of Radiation Oncology, CA 94305-5152, USA. akoong@stanford.edu
Abstract:
The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy.
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