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Updated: Aug 7, 2026

NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins
Published on: November 1, 2024
Removal of a time barrier for high-resolution multidimensional NMR spectroscopy
Victor Jaravine1, Ilgis Ibraghimov, Vladislav Yu Orekhov
1The Swedish NMR Centre at Gothenburg University, Box 465, 40530 Gothenburg, Sweden.
Abstract:
We introduce the recursive multidimensional decomposition (R-MDD) method to speed recording of high-resolution NMR spectra. The measurement time is logarithmically dependent on the sizes of indirect spectral dimensions. R-MDD has the sensitivity and resolution advantages of optimized nonuniform acquisition schemes and is applicable to all types of biomolecular spectra. We demonstrated it for triple resonance experiments on three globular proteins (ubiquitin, azurin and the barstar-barnase complex) of 8-22 kDa.
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