Related Experiment Video
Updated: Aug 7, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
The unexpected science of estrogen receptor-beta selective agonists: a new class of anti-inflammatory agents?
1Women's Health and Musculoskeletal Biology, Wyeth Research, Collegeville, PA, USA. harrish@wyeth.com
Abstract:
In the nine years since the unexpected discovery of a second form of the estrogen receptor (ER), ERbeta has been mentioned in about 2,800 literature citations. Such prolific research is testimony to interest in explaining its role in estrogen physiology as well as investigating its potential as a drug target. Our current understanding is that ERalpha, not ERbeta is responsible for mediating the effects of estrogens in "classic" model systems such as the reproductive tract and skeleton. The role of ERbeta is still being defined, but profiling of ERbeta selective agonists in several animal models of human disease indicates these compounds may have utility as novel anti-inflammatory agents. The challenge for the future is to elucidate their mechanism of action and determine the clinical relevance of the impressive preclinical observations.
Related Concept Videos
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Mitogens and the Cell Cycle
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Adrenergic Antagonists: Chemistry and Classification of β-Receptor Blockers
