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A high prevalence of parvovirus B19 DNA in patients with psoriasis

Ayca Cordan Yazici1, Gonul Aslan, Kiymet Baz

  • 1Department of Dermatology, School of Medicine, Mersin University, 33079, Mersin, Turkey. aycacordan@yahoo.com

Archives of Dermatological Research
|July 25, 2006
PubMed

Insights

Human parvovirus B19 (PVB19) DNA was significantly more prevalent in psoriasis patients than controls. This suggests PVB19 infection may play a role in the development of this common inflammatory skin disease.

Area of Science:

  • Immunology
  • Virology
  • Dermatology

Background:

  • Psoriasis is a common inflammatory skin condition.
  • Viral infections are implicated in psoriasis pathogenesis.
  • Human parvovirus B19 (PVB19) is linked to autoimmune and dermatologic conditions.

Purpose of the Study:

  • To investigate the potential role of PVB19 in psoriasis.
  • To analyze PVB19 DNA and antibody presence in psoriasis patients.

Main Methods:

  • Analyzed PVB19 DNA in peripheral blood of 47 psoriasis patients and 20 controls.
  • Detected anti-PVB19 IgG and IgM antibodies using ELISA.
  • Correlated PVB19 presence with clinical psoriasis characteristics.

Main Results:

  • PVB19 DNA was found in 38% of psoriasis patients versus 0% of controls (P < 0.01).
  • Anti-PVB19 IgG antibodies were detected in 79% of patients, indicating latent infection.
  • PVB19 DNA presence correlated with IgG seropositivity but not IgM.

Conclusions:

  • A significant association exists between psoriasis and PVB19 infection.
  • PVB19 may be a contributing factor in the pathophysiology of psoriasis.
  • Further research is warranted to elucidate the precise role of PVB19 in psoriasis.

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