Related Experiment Videos
Large bullous eruption in patients with ulcerative colitis
A Ishibashi1, K Yamaji, Y Hayashi
1Department of Dermatology, National Defense Medical College, Saitama, Japan.
The Journal of Dermatology
|September 1, 1991
Summary
Large, blistering skin eruptions in two ulcerative colitis patients resolved with treatment. These bullae appear to be a direct skin manifestation of the inflammatory bowel disease.
Area of Science:
- Dermatology
- Gastroenterology
- Internal Medicine
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
- Cutaneous manifestations can occur in patients with UC.
- Bullous eruptions are rare in UC patients.
Observation:
- Two patients with ulcerative colitis presented with oligocentric large bullous eruptions.
- The bullae resembled those seen in drug-induced coma or from high-dose frusemide.
- Neither patient had received narcotic drugs or frusemide.
Findings:
- Bullous eruptions in these patients were treated successfully with corticosteroids and/or salazosulfapyridine.
- The resolution of bullae paralleled the course of ulcerative colitis activity.
- This suggests a direct link between the bullae and UC.
Implications:
- Bullous eruptions may represent a specific cutaneous manifestation of ulcerative colitis.
- This finding expands the spectrum of dermatological conditions associated with UC.
- Further research is warranted to understand the pathogenesis of these bullae in UC.