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From functional genomics to functional immunomics: new challenges, old problems, big rewards.

Ulisses M Braga-Neto1, Ernesto T A Marques

  • 1Experimental Therapy Laboratory, Aggeu Magalhães Research Center - CPqAM/FIOCRUZ, Recife, Brazil. ub@ieee.org

Plos Computational Biology
|July 26, 2006
PubMed
Summary

Functional immunomics, an emerging field, uses immunomic microarray technology to study immune responses. This technology aids in identifying biomarkers for diseases like HIV, diabetes, and cancer, advancing systems biology.

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Area of Science:

  • Immunology
  • Genomics
  • Systems Biology

Background:

  • DNA microarray technology established functional genomics.
  • Immunomic microarray technology is emerging for large-scale measurement of specific immunological responses.
  • Functional immunomics presents new challenges and opportunities distinct from functional genomics.

Purpose of the Study:

  • To provide a vision of the nascent field of functional immunomics.
  • To discuss key aspects including epitope prediction, technology applications, and computational challenges.
  • To speculate on future research directions in functional immunomics.

Main Methods:

  • Review of immunomic microarray technology and its applications.
  • Discussion of computational and statistical challenges in functional immunomics.

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  • Exploration of epitope prediction methodologies.

    • Main Results:

    • Immunomic data has identified biomarkers for autoimmune diseases, allergies, viral infections (e.g., HIV, influenza), diabetes, and cancer vaccine responses.
    • The review highlights the potential of immunomic microarrays in advancing systems biology.
    • Insights into T cell response regulation mechanisms are discussed.

    Conclusions:

    • Functional immunomics is a rapidly developing field with significant potential.
    • Immunomic microarrays are valuable tools for understanding complex immune responses.
    • Future research will focus on immunomic regulatory network models for systems biology applications.