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Related Experiment Videos

Metabonomics in preclinical drug development.

Donald G Robertson1, Michael D Reily, J David Baker

  • 1Pfizer Global Research and Development, Department of World Wide Safety Sciences, 2800 Plymouth Rd, Ann Arbor, MI 48105, USA. donald.robertson@pfizer.com

Expert Opinion on Drug Metabolism & Toxicology
|July 26, 2006
PubMed
Summary

Metabonomics offers rapid, noninvasive safety assessment in preclinical drug development. Expertise in biology, analytical sciences, and chemometrics is crucial for effective implementation and data interpretation.

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Area of Science:

  • Preclinical drug discovery and development
  • Toxicology
  • Systems biology

Background:

  • Metabonomics is a key technology for assessing drug safety.
  • It allows for noninvasive, systems-level evaluation of compound effects.
  • Rapid, high-throughput analysis is possible on an individual animal basis.

Purpose of the Study:

  • To highlight the value of metabonomics in preclinical safety assessment.
  • To emphasize the necessary expertise for its effective implementation and data interpretation.
  • To position metabonomics as a valuable tool for toxicologists.

Main Methods:

  • Noninvasive systems assessment of biological responses.
  • Utilizing analytical sciences such as nuclear magnetic resonance (NMR) and mass spectrometry (MS).

Related Experiment Videos

  • Application of chemometrics for data analysis.

    • Main Results:

    • Metabonomics enables rapid characterization of a broad spectrum of biological responses.
    • It provides a systems-level view of untoward effects induced by candidate compounds.
    • The technology is suitable for early preclinical safety assessment.

    Conclusions:

    • Metabonomics is a valuable addition to preclinical drug safety assessment.
    • Successful implementation requires expertise in biological sciences, analytical sciences, and chemometrics.
    • Properly applied, metabonomics significantly enhances the capabilities of preclinical toxicologists.