An unusual cause of syncope

Area of Science:

• Endocrinology
• Oncology
• Cardiology

Background:

• Syncope is a common clinical presentation with diverse etiologies.
• Adrenal insufficiency can manifest with non-specific symptoms, complicating diagnosis.
• Drug-induced syncope is a frequent initial consideration in clinical practice.

Purpose of the Study:

• To report an unusual case of syncope secondary to hypoadrenalism.
• To highlight the diagnostic challenge posed by adrenal insufficiency mimicking other conditions.
• To emphasize the importance of comprehensive investigation for syncope.

Main Methods:

• Case report presentation.
• Review of patient's clinical history and investigations.
• Diagnostic workup including hormonal assays and imaging.

Main Results:

• Syncope was ultimately attributed to hypoadrenalism.
• The hypoadrenalism was found to be secondary to a primary breast tumor.
• Initial suspicion of drug-induced syncope was ruled out.

Conclusions:

• Primary breast tumors can rarely present with hypoadrenalism causing syncope.
• Thorough diagnostic evaluation is crucial when syncope is suspected.
• Timely diagnosis and management of adrenal insufficiency significantly improve patient outcomes and quality of life.