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Updated: Aug 7, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
Published on: March 10, 2021
[HLA-DM gene polymorphism in Cantonese with condyloma acuminata]
Wen-lin Yang1, Jian Yang, Sheng-qiang Chen
1Department of Dermatology, Second Affiliated Hospital, Guangzhou Medical College, Guangzhou 510260, China. yangwenlin@21cn.com
Objective:
To study the polymorphism of HLA-DM gene in Cantonese patients with condyloma acuminata(CA) and determine the susceptible genetic factors of CA.
Methods:
DMA and DMB typing was performed in 98 Cantonese patients with CA and 93 healthy controls using restriction fragment length polymorphism method.
Results:
The gene frequencies of DMA*0101 and DMB*0101 were significantly higher in the patients than in the controls (P<0.05 and P<0.01, respectively), and gene frequency of DMA*0102 was lower in patients than in the controls (P<0.01). Genotype frequencies of HLA-DM showed no significant difference between CA patients and the controls (P>0.05).
Conclusion:
DMA*0101 and DMB*0101 alleles may be the susceptibility genes or closely linked to the susceptibility gene in Cantonese patients with CA.
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