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Updated: Aug 7, 2026

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface
Published on: December 30, 2025
[Investigation of viral pathogens contributing to habitual abortion]
Wen-ling Jiang1, Zhao Liu, Zhan-qiu Yang
1Medical Reseach Center, People's Hospital of Guangdong Province, Guangzhou 510080, China. jwenling@126.com
Objective:
To investigate the association of Coxsackie B virus (CBV) with habitual abortion.
Methods:
CBV IgM antibody, viral RNA and virions were detected in 86 women with habitual abortion and 40 with induced abortion by means of enzyme-linked immunosorbent assay (ELISA), RT-PCR and virus isolation, respectively.
Results:
The positivity rate of CBV IgM were 87.2% and 35% in the two groups, respectively, and the detection rate of the viral RNA was 53.5% and 17.5% in blood lymphocytes, and 59.3% and 17.5% in the placentas. The virions were found in the placentas in 41.9% and 6.9% of the women, respectively. The positivity rates of CBV IgM, viral DNA and virions showed significant difference between the two groups (P<0. 01).
Conclusion:
CBV might be one of the causes responsible for habitual abortion.
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