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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Microvascular obstruction and myocardial function after acute myocardial infarction: assessment by using

Gilbert L Raff1, William W O'Neill, Ralph E Gentry

  • 1Cardiology Division, Department of Internal Medicine, William Beaumont Hospital, 3601 W 13 Mile Rd, Royal Oak, MI 48073-6769, USA. graff@beaumont.edu

Radiology
|July 26, 2006
PubMed
Abstract

Insights

Contrast-enhanced cine MRI improves evaluation of microvascular obstruction after myocardial infarction. This advanced imaging technique reduces scan time and enhances spatial resolution without affecting myocardial function assessment.

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Medical Diagnostics

Background:

  • Acute myocardial infarction (AMI) requires effective imaging for assessing microvascular obstruction and myocardial function post-reperfusion therapy.
  • Standard magnetic resonance (MR) imaging techniques provide valuable data but may have limitations in speed and resolution.

Purpose of the Study:

  • To prospectively compare contrast material-enhanced cine MR imaging with standard MR imaging.
  • To evaluate the efficacy of contrast-enhanced cine MR imaging in assessing microvascular obstruction and myocardial function in patients with AMI.
  • To determine if contrast enhancement impacts myocardial function parameters.

Main Methods:

  • Prospective study involving 80 patients with acute myocardial infarction post-reperfusion therapy.
  • Comparison of contrast-enhanced cine MR imaging with standard MR imaging techniques.
  • Assessment of microvascular obstruction using first-pass perfusion and inversion-recovery gradient-echo sequences.
  • Evaluation of myocardial function parameters before and after contrast enhancement.

Main Results:

  • Contrast-enhanced cine MR imaging showed strong agreement with standard MR imaging for assessing global and transmural microvascular obstruction (IC values ranging from 0.88 to 0.96, P < .001).
  • No significant differences were observed in myocardial function parameters before and after contrast material enhancement.
  • Contrast-enhanced cine MR imaging significantly reduced imaging time by 34% and improved spatial resolution.

Conclusions:

  • Contrast-enhanced cine MR imaging is a reliable and efficient method for evaluating microvascular obstruction in patients with acute myocardial infarction.
  • This technique offers advantages in reduced imaging time and improved spatial resolution compared to standard MR imaging.
  • Contrast-enhanced cine MR imaging does not adversely affect the assessment of myocardial function.

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