Long-term outcome after neuroleptic malignant syndrome

Neuroleptic malignant syndrome (NMS) is a rare, life-threatening adverse drug reaction caused by the blockade of central dopaminergic receptors by neuroleptics. In the acute phase, most patients recover, although marked mortality from complications of acute NMS still exist. The long-term course after acute NMS is, however, still unclear. In this report we describe the follow-up data from 12 patients.