Related Experiment Video

Updated: Aug 6, 2026

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

Global and regional left ventricular function: a comparison between gated SPECT, 2D echocardiography and multi-slice

Maureen M Henneman1, Jeroen J Bax, Joanne D Schuijf

  • 1Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

European Journal of Nuclear Medicine and Molecular Imaging
|July 26, 2006
PubMed

Insights

Multi-slice computed tomography (MSCT) can effectively assess left ventricular (LV) function in coronary artery disease (CAD) patients. MSCT shows excellent correlation with 2D echocardiography for LV volumes and function.

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Cardiac Diagnostics

Background:

  • Left ventricular (LV) function is crucial for assessing cardiac status in coronary artery disease (CAD).
  • Non-invasive assessment of coronary arteries using multi-slice computed tomography (MSCT) is established.
  • Retrospective ECG-gating in MSCT allows for derivation of LV function data.

Purpose of the Study:

  • To evaluate the capability of MSCT in assessing global and regional LV function and volumes in patients with CAD.
  • To compare the accuracy of MSCT-derived LV function parameters with those obtained from gated SPECT and 2D echocardiography.

Main Methods:

  • Coronary angiography with MSCT was performed in 49 patients with known or suspected CAD.
  • LV end-diastolic volume, LV end-systolic volume, and LV ejection fraction were analyzed using dedicated software.
  • Regional wall motion was assessed using a 17-segment model and a three-point score system, compared against gated SPECT and 2D echocardiography.

Main Results:

  • MSCT demonstrated good correlations with gated SPECT for LV volumes (r=0.63-0.65) and ejection fraction (r=0.60).
  • MSCT showed excellent correlations with 2D echocardiography for LV volumes (r=0.92-0.93) and ejection fraction (r=0.80).
  • Agreement for regional wall motion was high between MSCT and 2D echocardiography (96%, kappa=0.73) and gated SPECT (95%, kappa=0.66).

Conclusions:

  • MSCT is an adequate imaging modality for assessing global and regional LV function and volumes in CAD patients.
  • The correlation between MSCT and 2D echocardiography for LV function assessment is stronger than that with gated SPECT.
Abstract

More Related Videos

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

Related Concept Videos

Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...