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Updated: Aug 6, 2026
Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
Published on: February 24, 2018
Fluorimetric analysis of mebendazole and flubendazole with hydrogen peroxide
W Baeyens1, F A Fattah, P De Moerloose
1Department of Pharmaceutical Chemistry and Drug Quality Control, Faculty of Pharmaceutical Sciences, State University of Ghent, Harelbekestraat 72, B-9000-Ghent, Belgium.
Abstract:
Analytically useful fluorescence was obtained from mebendazole and flubendazole after reaction with hydrogen peroxide in alkaline solution. The fluorescence produced (lambda(ex) = 300 nm; lambda(em) = 360 nm) is stable and concentrations of 0.1 mug ml(-1) can be determined. The method has been applied to the analysis of some commercially available anthelmintic preparations.
