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Related Experiment Videos

The physicochemical properties of digoxin.

M Draguet-Brughmans1, R Bouche, C Lefebvre

  • 1Laboratoire d'Analyse des Médicaments, Université Catholique de Louvain, 7340 avenue Mounier, 73, 1200 Bruxelles, Belgium.

Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1985
PubMed
Summary

Digoxin

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Area of Science:

  • Pharmaceutical Sciences
  • Solid-State Chemistry

Background:

  • Digoxin is a cardiac glycoside used to treat heart conditions.
  • Variations in commercial digoxin powder properties necessitate understanding its solid forms.

Purpose of the Study:

  • To investigate the physicochemical properties of digoxin powder from various commercial sources.
  • To characterize different solid forms of digoxin, including crystalline and amorphous states.

Main Methods:

  • Recrystallization of digoxin under various conditions.
  • Characterization of amorphous and crystalline digoxin forms.
  • Solubility and stability studies under compression and aqueous contact.

Main Results:

  • A pure amorphous form of digoxin was obtained under specific conditions, with no polymorphs observed.
  • The amorphous form exhibited higher solubility and stability under compression but rapidly crystallized in water.
  • Presence of crystalline digoxin traces significantly reduced the amorphous form's dissolution rate and stability.
  • Thermal behavior variations in commercial samples are attributed to amorphous content and thermal decomposition above 160°C.

Conclusions:

  • Digoxin exists in both crystalline and amorphous forms, with the amorphous form being more soluble and stable under compression.
  • The amorphous form's stability is compromised by water contact and crystalline impurities.
  • Understanding these solid-state properties is crucial for consistent digoxin formulation and therapeutic efficacy.

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