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Related Experiment Videos

A quinidine-responsive plastic membrane electrode.

V V Cosofret1, R P Buck

  • 1Department of Chemistry, University of North Carolina, Chapel Hill, NC 27514, USA.

Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1985
PubMed
Summary
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A new quinidine tetraphenylborate electrode in a PVC matrix offers rapid, near-Nernstian detection of quinidine sulphate in pharmaceutical preparations. This sensor also responds to diprotonated quinidine and tetraphenylboron ions.

Area of Science:

  • Electrochemistry
  • Analytical Chemistry
  • Materials Science

Background:

  • Development of ion-selective electrodes (ISEs) is crucial for accurate chemical analysis.
  • Quinidine determination in pharmaceuticals requires sensitive and reliable methods.
  • PVC matrix membranes offer good stability and processability for ISEs.

Purpose of the Study:

  • To develop and characterize a novel membrane electrode for quinidine detection.
  • To evaluate the electrode's performance in various conditions and concentration ranges.
  • To assess the electrode's applicability in the analysis of pharmaceutical samples.

Main Methods:

  • Fabrication of a PVC matrix membrane electrode incorporating quinidine tetraphenylborate.
  • Potentiometric measurements to assess electrode response to quinidine sulphate.

Related Experiment Videos

  • Testing electrode performance across different pH values and concentrations.
  • Evaluation of response to diprotonated quinidine and tetraphenylboron (TPB-) ions.
  • Application of direct potentiometry and potentiometric titrations for pharmaceutical analysis.

    • Main Results:

    • The electrode demonstrated a rapid and near-Nernstian response for quinidine sulphate within the 3.5 x 10(-5) to 1 x 10(-2) M range at pH 6-8.
    • A linear response was observed for tetraphenylboron (TPB-) ions from 10(-4) to 10(-2) M.
    • The electrode showed sensitivity to diprotonated quinidine in acidic media.
    • Successful determination of quinidine in pharmaceutical preparations using direct potentiometry and potentiometric titrations.

    Conclusions:

    • The developed quinidine tetraphenylborate PVC membrane electrode is a viable sensor for quinidine determination.
    • The electrode exhibits good performance characteristics, including rapid response and wide linear range.
    • The sensor shows potential for quality control applications in the pharmaceutical industry.