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Updated: Aug 6, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Fully-automated assay by liquid chromatography for routine drug monitoring in body fluids--method development with
1Department of Biochemistry, Dr. K. Thomae GmbH, Postfach 17 55, 7950 Biberach, FRG.
Abstract:
A fully-automated liquid chromatograph based on alternated pre-column enrichment technique has been developed for routine drug monitoring of body fluids using a column switching technique. Advantages of the method include the facility of direct injection of the body fluid onto the chromatograph and the simultaneous detection of both polar and non-polar metabolites under isocratic or gradient elution conditions.
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