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[Not Available].

R Bouche1

  • 1Laboratoire d'Analyse des Médicaments, Université Catholique de Louvain, avenue E. Mounier 73, 1200 Bruxelles, Belgique.

Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1983
PubMed
Summary

Drug polymorphism, the existence of different crystal forms, impacts drug quality control and bioavailability. Understanding polymorph characterization is key to ensuring effective drug development and patient safety.

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Area of Science:

  • Solid-state chemistry
  • Pharmaceutical sciences
  • Materials science

Context:

  • Polymorphism is a critical factor in pharmaceutical development.
  • Ensuring consistent drug quality and efficacy relies on understanding solid-state properties.
  • The relationship between drug form and therapeutic effect is increasingly recognized.

Purpose:

  • To discuss the role of polymorphism in the evolution of drug quality control.
  • To demonstrate the potential link between drug polymorphism and bioavailability.
  • To describe the advantages and limitations of polymorph characterization techniques.

Summary:

  • Polymorphism significantly influences drug quality control strategies.
  • A correlation between drug polymorphism and bioavailability has been demonstrated.
  • Various techniques for characterizing drug polymorphs have been evaluated for their strengths and weaknesses.

Impact:

  • Provides insights into optimizing drug formulation for enhanced bioavailability.
  • Informs regulatory strategies for drug quality assessment.
  • Highlights the importance of solid-state characterization in pharmaceutical manufacturing.

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