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Drug effects on clinical laboratory tests.
G Siest1, S J Dawkins, M M Galteau
1Centre du Médicament, Université de Nancy I, 7 rue Albert Lebrun, 54000 Nancy, France.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1983
Summary
Drugs and xenobiotics significantly impact clinical laboratory test results through analytical interference and biological effects. Understanding these drug influences is crucial for accurate testing and effective patient treatment monitoring.
Area of Science:
- Clinical Chemistry
- Pharmacology
- Laboratory Medicine
Background:
- Drugs and xenobiotics are known to alter clinical laboratory test outcomes.
- Both analytical interference and biological modulation by external compounds are recognized issues.
- Standardized protocols for studying these effects are being developed by scientific bodies.
Purpose of the Study:
- To survey laboratory studies on drug effects in routine clinical screening.
- To describe a database for patient information and drug effect literature.
- To highlight the importance of understanding drug influences on laboratory diagnostics.
Main Methods:
- Reviewing laboratory studies involving thousands of patients undergoing clinical screening.
- Developing a database to store patient data and published literature on drug effects.
- Analyzing analytical interferences and biological effects (physiological, pharmacological, toxicological).
Main Results:
- Analytical interferences can be reduced by highly specific analytical techniques.
- Biological effects can be beneficial, e.g., monitoring hazardous drug treatments.
- The need for well-defined reference populations and comprehensive patient data is emphasized.
Conclusions:
- Greater awareness of drug effects on laboratory results is necessary.
- Exploiting drug-induced biological effects can aid in toxicity monitoring and personalized medicine.
- Health professions should leverage these effects for improved patient care and medication management.