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A novel human sex-determining gene linked to Xp11.21-11.23

Singh Rajender1, Kumarasamy Thangaraj, Nalini J Gupta

  • 1Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India.

The Journal of Clinical Endocrinology and Metabolism
|July 27, 2006
PubMed
Abstract

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The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
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The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
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In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
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