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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
The epidemics of cardiovascular disease in elderly patients with chronic kidney disease--two facets of the same
Adrian Covic1, Paul Gusbeth-Tatomir, David J A Goldsmith
1Nephrology Clinic and Dialysis and Transplantation Center, C. I. PARHON University Hospital, 6600, Iasi, Romania. acovic@xnet.ro
Insights
Mild kidney dysfunction significantly increases cardiovascular risk in the elderly. Early identification and treatment of cardiovascular disease (CVD) in chronic kidney disease (CKD) patients are crucial for improved survival.
Area of Science:
- Nephrology
- Cardiology
- Geriatrics
Background:
- Chronic kidney disease (CKD) disproportionately affects the elderly population.
- Cardiovascular disease (CVD) is a major cause of mortality in patients with CKD, especially those on dialysis.
- Elderly individuals with renal impairment often receive suboptimal cardiovascular care.
Purpose of the Study:
- To review recent literature on cardiovascular disease in elderly patients with CKD.
- To highlight the association between renal dysfunction and cardiovascular risk.
- To emphasize the need for early detection and management of CVD in this demographic.
Main Methods:
- Literature review of studies published in the last decade.
- Focus on data concerning elderly individuals with CKD and CVD.
- Synthesis of evidence on cardiovascular risk factors and outcomes.
Main Results:
- Increasing evidence links even mild renal dysfunction to potent cardiovascular risk in the elderly.
- Cardiovascular risk escalates proportionally with the severity of renal impairment.
- Congestive heart failure significantly worsens survival rates in the dialysis population.
Conclusions:
- Cardiovascular risk factors must be identified and managed early in CKD patients.
- There is a critical need to improve cardiovascular therapy for elderly CKD patients.
- Addressing CVD in the aging CKD population is essential for enhancing patient outcomes.
Abstract:
There is increasing evidence that even mild renal dysfunction is a novel potent cardiovascular risk factor in the general elderly population. With more severe renal impairment, cardiovascular risk increases proportionately. This issue deserves attention, as chronic kidney disease (CKD) is predominantly a disease of the elderly, and the mean age of end-stage renal disease patients entering dialysis is growing constantly. In the dialysis population, when clinically significant cardiovascular disease (CVD) (particularly congestive heart failure) is present, survival is worse. Thus, every effort should be made to identify and treat cardiovascular risk factor in the early stages of CKD. However, elderly renal patients receive less proper cardiovascular therapy compared to non-renal subjects of the same age. This review deals briefly with the most significant data published in the last decade on CVD in elderly with CKD.
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