Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Codeine and 6-acetylcodeine analgesia in mice.

Steven Milo1, Michael Ansonoff, Michael King

  • 1Laboratory of Molecular Neuropharmacology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, New York 10021, USA.

Cellular and Molecular Neurobiology
|July 27, 2006
PubMed
Summary

6-acetylcodeine exhibits analgesic properties similar to codeine but possesses a unique pharmacological profile. Its distinct mu opioid receptor interaction differentiates it from other related analgesics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic.

ACS chemical neuroscience·2025
Same author

Exploring trust dynamics in health information systems: the impact of patients' health conditions on information source preferences.

Frontiers in public health·2024
Same author

Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models.

Nature communications·2024
Same author

Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment.

Genes, brain, and behavior·2022
Same author

Exploring Pharmacological Functions of Alternatively Spliced Variants of the Mu Opioid Receptor Gene, <i>Oprm1</i>, via Gene-Targeted Animal Models.

International journal of molecular sciences·2022
Same author

Oxidative Metabolism as a Modulator of Kratom's Biological Actions.

Journal of medicinal chemistry·2021

Area of Science:

  • Pharmacology
  • Neuroscience
  • Medicinal Chemistry

Background:

  • Acetylation of morphine at the 6-position alters its pharmacological properties.
  • Investigating similar modifications in codeine could reveal new analgesic mechanisms.

Purpose of the Study:

  • To compare the analgesic actions of codeine and its acetylated derivative, 6-acetylcodeine.
  • To characterize the pharmacological profile of 6-acetylcodeine as a mu opioid analgesic.

Main Methods:

  • Assessment of analgesic efficacy across systemic, supraspinal, and spinal administration routes.
  • Evaluation of sensitivity to mu-selective antagonists (beta-FNA, naloxonazine).
  • Antisense mapping targeting the mu opioid receptor gene (Oprm) exons 1 and 2.

Related Experiment Videos

Main Results:

  • 6-acetylcodeine demonstrated analgesic effects comparable to codeine, with approximately one-third of its potency.
  • Its analgesia was confirmed as mu opioid-mediated but showed distinct responses to antagonists compared to other mu analgesics.
  • Antisense mapping revealed a unique sensitivity profile for 6-acetylcodeine, differing from codeine and morphine.

Conclusions:

  • 6-acetylcodeine is an effective mu opioid analgesic.
  • It possesses a distinct pharmacological profile, particularly in its interaction with the mu opioid receptor gene.
  • This distinct profile suggests potential for novel therapeutic applications or understanding of opioid receptor signaling.