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Protein binding of cefpiramide in the plasma of various species
T Ohshima1, T Hasegawa, I Johno
1Department of Hospital Pharmacy, School of Medicine, Nagoya University, Japan.
The Journal of Pharmacy and Pharmacology
|November 1, 1991
Abstract:
The plasma protein binding of cefpiramide in man, dog, rabbit and rat was examined. Cefpiramide was more strongly bound to human plasma than to animal plasma and was exclusively bound to albumin. The characteristics of the protein binding of cefpiramide is one of the factors influencing the extrapolation of drug disposition from animals to man.