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Published on: September 6, 2017
Lutheran b blood group alloimmunization: case series and literature review
Shabnam Kashani1, Robert J Stiller
1Department of Obstetrics and Gynecology, Bridgeport Hospital, USA.
Abstract:
The Lutheran b blood antigen is a high prevalence antigen occurring in 99.8% of Caucasians. Consequently, antibody formation against Lutheran b is very rare. While this antibody can cause hemolytic reactions in adults, there is limited clinical information on its effects on the fetus and newborn. As a high prevalence antigen, it may be difficult to obtain Lutheran b-negative blood for possible maternal transfusion. We describe two cases of pregnancy complicated by Lutheran b alloimmunization. These cases highlight the potential fetal and maternal complications associated with this antibody and we review options to maximize perinatal outcome.
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