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Aggressive angiomyxoma: multimodality treatments can avoid mutilating surgery.

I J M Han-Geurts¹, A N van Geel, L van Doorn

¹Department of Surgical Oncology, Erasmus Medical Centre/Daniel den Hoed Cancer Centre, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

|July 28, 2006

Summary

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Aggressive angiomyxoma, a pelvic tumor, often recurs. Extensive surgery may not reduce recurrence rates compared to less invasive methods like embolization, questioning its necessity due to morbidity.

Area of Science:

Oncology
Surgical Pathology
Gynecologic Oncology

Background:

Aggressive angiomyxoma is a rare soft-tissue tumor originating in the pelvi-perineal region.
This tumor has a high recurrence rate, often necessitating extensive surgical resections with significant patient morbidity.

Purpose of the Study:

To evaluate alternative treatment strategies for aggressive angiomyxoma.
To assess the recurrence rates and clinical outcomes associated with different treatment modalities.

Main Methods:

Retrospective review of seven patient medical charts over 20 years.
Inclusion of follow-up data for all patients.
Literature review of aggressive angiomyxoma treatment from 1994-2004.

Main Results:

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Seven female patients, three pregnant at diagnosis, underwent primary surgery.
Five patients had positive surgical margins; one received adjuvant radiotherapy.
Three patients experienced four recurrences, treated with embolization or surgery; all patients are currently disease-free.

Conclusions:

Radical surgery does not appear to significantly lower recurrence rates compared to incomplete resection (R1).
Adjuvant radiotherapy or arterial embolization may be effective in managing aggressive angiomyxoma.
The necessity of extensive surgery is questioned due to potential morbidity and similar recurrence rates.