Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

pH-responsive micelles and vesicles nanocapsules based on polypeptide diblock copolymers.

F Chécot1, J Rodríguez-Hernández, Y Gnanou

  • 1Laboratoire de Chimie des Polymères Organiques (LCPO-UMR5629), CNRS, ENSCPB, University Bordeaux 1, 16 Avenue Pey Berland, 33607 Pessac-Cedex, France.

Biomolecular Engineering
|July 28, 2006
PubMed
Summary

Researchers developed stimuli-responsive nanoparticles from polypeptide-based diblock copolymers. These nanoparticles exhibit controlled size and shape, showing promise for targeted encapsulation and delivery applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing road performance and sustainability: A study on recycled porous warm mix asphalt.

The Science of the total environment·2025
Same author

Impact of metal exchange on the electronic structure and optical properties of isostructural octa-coordinated Mo<sup>IV</sup>/Cd<sup>II</sup> and W<sup>IV</sup>/Cd<sup>II</sup> polynuclear cyanide polymers.

Dalton transactions (Cambridge, England : 2003)·2024
Same author

A first principles study of the electronic structure and optical response of heterobimetallic M-dicyanoaurate-based coordination polymers (M = Mn, Co, Ni, Zn and Cd).

Physical chemistry chemical physics : PCCP·2024
Same author

Nucleic acids complexation with cationic elastin-like polypeptides: Stoichiometry and stability of nano-assemblies.

Journal of colloid and interface science·2019
Same author

Organogels from trehalose difatty ester amphiphiles.

Soft matter·2019
Same author

Electro-responsive polyelectrolyte-coated surfaces.

Faraday discussions·2017

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Polypeptide-based diblock copolymers self-assemble into nanostructures.
  • Stimuli-responsive materials are crucial for targeted applications.

Purpose of the Study:

  • To investigate the self-assembly of polypeptide-based diblock copolymers into micelles and vesicles.
  • To explore the stimuli-responsive behavior of these nanoparticles for controlled size and shape.
  • To evaluate their potential in biomedical applications, particularly for encapsulation and delivery.

Main Methods:

  • Static and dynamic light scattering analysis
  • UV circular dichroism
  • Nuclear Magnetic Resonance (NMR)
  • Small-angle neutron scattering (SANS)

Related Experiment Videos

Main Results:

  • Well-defined micelles and vesicles were formed from polypeptide-based diblock copolymers.
  • Nanoparticle size and shape were controlled by pH and ionic strength.
  • Systems forming vesicles with narrow size distribution at varying pH were identified, passing through a single-molecule intermediate state.

Conclusions:

  • Polypeptide-based diblock copolymer nanoparticles offer tunable properties for controlled self-assembly.
  • These nanoparticles are promising for biomedical applications requiring pH-responsive encapsulation and delivery.
  • The ability to form vesicles with controlled size at different pH levels is a significant advancement.