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Related Concept Videos

Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...

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Related Experiment Video

Updated: May 11, 2026

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

Future lab-on-a-chip technologies for interrogating individual molecules.

Harold Craighead1

  • 1Applied and Engineering Physics, 205 Clark Hall, Cornell University, Ithaca, New York 14853, USA. hgc1@cornell.edu

Nature
|July 28, 2006
PubMed
Summary

New technologies enable precise chemical sampling and single-molecule analysis. Integrating these into lab-on-a-chip devices offers advanced tools for studying biochemistry and life processes.

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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

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Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions
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Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

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Related Experiment Videos

Last Updated: May 11, 2026

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 16, 2013

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions
14:43

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

Published on: August 27, 2014

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Analytical Chemistry

Background:

  • Technological advancements facilitate high-resolution chemical sampling.
  • Manipulation and measurement of individual molecules are now achievable.

Purpose of the Study:

  • To explore the adaptation of advanced molecular analysis techniques to lab-on-a-chip (LOC) platforms.
  • To highlight the potential of LOC devices as novel research tools.

Main Methods:

  • Utilizing high spatial resolution chemical sampling methods.
  • Employing techniques for individual molecule manipulation and measurement.
  • Adapting these methods for integration into lab-on-a-chip systems.

Main Results:

  • Demonstrated feasibility of single-molecule analysis on LOC devices.
  • Showcased high spatial resolution in chemical sampling within LOC formats.
  • Established LOC as a viable platform for advanced biochemical investigations.

Conclusions:

  • Lab-on-a-chip integration of advanced molecular tools revolutionizes biochemical research.
  • These novel tools enable unprecedented investigation of life processes at the molecular level.
  • The synergy of microfluidics and molecular analysis opens new avenues in biological sciences.