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iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Related Experiment Video

Updated: May 5, 2026

Patterning of Embryonic Stem Cells Using the Bio Flip Chip

Patterning of Embryonic Stem Cells Using the Bio Flip Chip

Published on: October 1, 2007

Cells on chips.

Jamil El-Ali¹, Peter K Sorger, Klavs F Jensen

¹Department of Chemical Engineering, Center for Cell Decision Processes, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

|July 28, 2006

Summary

This summary is machine-generated.

Microsystems offer advanced control over cell growth and stimuli by integrating biomimetic surfaces and microfluidics. These multifunctional platforms advance biological research and enable portable point-of-care devices for diverse clinical settings.

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Last Updated: May 5, 2026

Patterning of Embryonic Stem Cells Using the Bio Flip Chip

Patterning of Embryonic Stem Cells Using the Bio Flip Chip

Published on: October 1, 2007

Chip-based Three-dimensional Cell Culture in Perfused Micro-bioreactors

Chip-based Three-dimensional Cell Culture in Perfused Micro-bioreactors

Published on: May 22, 2008

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 16, 2013

Area of Science:

Biomedical Engineering
Cell Biology
Microfluidics

Background:

Microsystems integrate biomimetic surfaces and microfluidic channels.
These systems enable precise spatial and temporal control of cell growth and stimuli.
Integration with bioanalytic microsystems creates multifunctional platforms.

Purpose of the Study:

To explore the potential of integrated microsystems for biological research and diagnostics.
To highlight the applications of microfluidic devices in controlling cellular environments.
To showcase the development of cell-based sensors for various functions.

Main Methods:

Combining surfaces mimicking extracellular matrix with microfluidic channels.
Utilizing bioanalytic microsystems for enhanced functionality.
Developing integrated microdevices for research and clinical applications.

Main Results:

Microsystems provide novel opportunities for controlling cell growth and stimuli.
Multifunctional platforms facilitate basic biological insights and cell-based sensing.
Highly integrated microdevices show promise for biomedical and pharmaceutical research.

Conclusions:

Integrated microsystems offer significant potential for advancing basic research.
Portable point-of-care devices derived from these microdevices can benefit clinical settings globally.
Microsystems represent a key technology for future biomedical innovation.