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Thyrotropin-releasing hormone excites submucous neurons in guinea-pig ileum
D H Zafirov1, H J Cooke, J D Wood
1Department of Physiology, College of Medicine, Ohio State University, Columbus 43210.
Actions of thyrotropin-releasing hormone (TRH) on submucous neurons of the guinea-pig ileum were examined with intracellular electrophysiological methods. TRH evoked excitatory responses in S/type 1 and AH/type 2 neurons. The responses consisted of slowly activating membrane depolarization, augmented excitability and an increase in input resistance that resulted from a decrease in potassium conductance. The results suggest a neuromodulatory/neurotransmitter function for TRH.
Actions of thyrotropin-releasing hormone (TRH) on submucous neurons of the guinea-pig ileum were examined with intracellular electrophysiological methods. TRH evoked excitatory responses in S/type 1 and AH/type 2 neurons. The responses consisted of slowly activating membrane depolarization, augmented excitability and an increase in input resistance that resulted from a decrease in potassium conductance. The results suggest a neuromodulatory/neurotransmitter function for TRH.