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Gout and the risk of acute myocardial infarction

Eswar Krishnan1, Joshua F Baker, Daniel E Furst

  • 1University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. Arthritis.MD@gmail.com

Arthritis and Rheumatism
|July 28, 2006
PubMed

Insights

Hyperuricemia and gouty arthritis are confirmed independent risk factors for acute myocardial infarction (MI). This increased risk is not explained by kidney function, metabolic syndrome, or other common cardiovascular risk factors.

Area of Science:

  • Cardiology
  • Rheumatology
  • Epidemiology

Background:

  • Hyperuricemia and gouty arthritis are associated with cardiovascular disease.
  • Their independent risk for acute myocardial infarction (MI) requires clarification, especially concerning confounding factors.

Purpose of the Study:

  • To determine if hyperuricemia and gouty arthritis are independent risk factors for acute MI.
  • To assess if this risk is independent of renal function, diuretic use, metabolic syndrome, and other established risk factors.

Main Methods:

  • Utilized multivariable logistic and instrumental variable probit regressions.
  • Analyzed data from the Multiple Risk Factor Intervention Trial (MRFIT) involving 12,866 men followed for a mean of 6.5 years.

Main Results:

  • Hyperuricemia was an independent risk factor for acute MI (OR 1.11, P < 0.001).
  • Gout was associated with a higher risk of acute MI (OR 1.26, P < 0.001), independent of covariates.
  • This association persisted across various subgroups, including those without metabolic syndrome, diabetes, or obesity.

Conclusions:

  • The independent risk of hyperuricemia for acute MI is confirmed.
  • Gouty arthritis is linked to an excess risk of acute MI, independent of known associated conditions and traditional cardiovascular risk factors.
Abstract

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