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Bisabolanes from the red alga Laurencia scoparia
Danilo Davyt1, Rafael Fernandez, Leopoldo Suescun
1Facultad de Química, Universidad de la República, Avenida Gral. Flores 2124, Montevideo, Uruguay.
Abstract:
Three novel halogenated beta-bisabolene sesquiterpenoids (1-3), together with two know triquinane alcohol sesquiterpenes (6 and 7), were isolated from the red alga Laurencia scoparia and their structures elucidated by spectroscopic methods. Single-crystal X-ray crystallography allowed us to confirm the structure of 1 as well as to determine the absolute configuration of all stereocenters. To the best of our knowledge, the isolation of beta-bisabolenes from the genus Laurencia has no precedent in the literature. Compound 1 showed weak in vitro anthelmintic activity against parasitant stage (L4) Nippostrongilus brasiliensis.
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