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Related Experiment Videos

Buspirone, ipsapirone and 1-(2-pyrimidinyl)-piperazine decrease cold-induced thyrotropin secretion in rats.

P Broqua1, V Baudrie, M T Bluet-Pajot

  • 1Laboratoire de Pharmacologie, Groupe de Neuropharmacologie, CNRS, Paris, France.

European Journal of Pharmacology
|November 5, 1991
PubMed
Summary
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Antidepressants buspirone and ipsapirone, and their metabolite 1-PP, reduce cold-induced TSH secretion in rats. Central 5-HT1A receptors and alpha 2-adrenoceptors appear to mediate these effects.

Area of Science:

  • Neuroendocrinology
  • Pharmacology

Background:

  • Thyrotropin (TSH) secretion is influenced by various neurochemical pathways.
  • Antidepressants and anxiolytics targeting serotonin receptors, like buspirone and ipsapirone, modulate neuroendocrine functions.
  • Alpha 2-adrenoceptors play a role in regulating hormone release.

Purpose of the Study:

  • To investigate the effects of buspirone, ipsapirone, their metabolite 1-(2-pyrimidinyl)-piperazine (1-PP), and specific 5-HT1A receptor agonists on cold-induced TSH secretion in rats.
  • To elucidate the roles of central 5-HT1A receptors and alpha 2-adrenoceptors in mediating these effects.

Main Methods:

  • Conscious catheterised rats were used to measure TSH secretion.
  • Intravenous administration of buspirone, ipsapirone, 1-PP, 8-hydroxy-2-(d-n-propylamino)tetralin (8-OH-DPAT), and N,N-dipropyl-5-carboxamidotryptamine (DP-5-CT) at various doses.

Related Experiment Videos

  • Assessment of TSH secretion in response to cold stress and TSH-releasing hormone (TRH) stimulation.

    • Main Results:

    • Buspirone, ipsapirone, and 1-PP dose-dependently decreased cold-induced TSH secretion.
    • 1-PP showed a preventive effect at a lower dose (3 mg/kg) compared to the parent compounds (10 mg/kg).
    • Central 5-HT1A agonist (8-OH-DPAT) diminished, while peripheral agonist (DP-5-CT) only diminished TSH secretion at the highest dose.
    • 1-PP pretreatment diminished TRH-induced TSH secretion, unlike buspirone or ipsapirone.

    Conclusions:

    • Azapirones (buspirone, ipsapirone) and their metabolite 1-PP inhibit cold-induced TSH secretion in rats.
    • Both central 5-HT1A receptors and alpha 2-adrenoceptors are implicated in mediating the TSH-lowering effects of azapirones.
    • The metabolite 1-PP may play a significant role in the observed neuroendocrine effects.