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Published on: July 14, 2017

Porokeratosis of Mibelli induced by topical corticosteroid

Figen Yazkan1, Bengu Gerceker Turk, Tugrul Dereli

  • 1Department of Dermatology, Ege University Medical Faculty, Bornova-Izmir, Turkey.

Journal of Cutaneous Pathology
|July 29, 2006
PubMed
Abstract

Insights

Prolonged use of topical steroids for psoriasis may lead to the development of porokeratosis of Mibelli, a skin condition characterized by unique lesions. This suggests a link between immunosuppression and porokeratosis.

Area of Science:

  • Dermatology
  • Histopathology

Background:

  • Porokeratosis of Mibelli is a chronic skin condition presenting with atrophic plaques and keratotic borders.
  • It affects skin health and requires careful management.

Observation:

  • A 45-year-old patient with a 15-year history of topical clobetasol propionate use for psoriasis developed porokeratosis Mibelli lesions on the elbows.
  • The case presented with a unique dermatological finding described as 'psoriasis encircled by porokeratosis'.

Findings:

  • Histopathological examination revealed characteristic cornoid lamellae at the specimen edges.
  • Psoriasiform acanthosis and spongiotic pustule formation were observed in the central specimen area.

Implications:

  • Prolonged topical steroid use may induce porokeratosis due to local immunosuppressive effects.
  • This finding highlights potential iatrogenic causes of skin disorders and the need for monitoring treatment side effects.

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