Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sympus monopus accompanied by nephroblastoma--A case report.

A Kimura, E Kudo, Y Hamamoto

    Acta Pathologica Japonica
    |May 1, 1975
    PubMed
    Summary

    This report details an autopsy of a rare sirenomelia case with nephroblastoma and multiple congenital anomalies. The findings highlight complex developmental abnormalities in a fetus with sympus monopus malformation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Expression of the vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation.

    Cancer research·1995
    Same author

    Differences in MHC class I self peptide repertoires among HLA-A2 subtypes.

    Journal of immunology (Baltimore, Md. : 1950)·1995
    Same author

    HLA-linked susceptibility and resistance genes in Crohn's disease.

    Gastroenterology·1995
    Same author

    HLA A2601-restricted CTLs recognize a peptide antigen expressed on squamous cell carcinoma.

    Cancer research·1995
    Same author

    Hippocampal homosynaptic long-term depression/depotentiation induced by adrenal steroids.

    Neuroscience·1995
    Same author

    Synthesis of 19-hydroxylated bile acids and identification of 3 alpha,7 alpha,12 alpha,19-tetrahydroxy-5 beta-cholan-24-oic acid in human neonatal urine.

    Chemical & pharmaceutical bulletin·1995

    Area of Science:

    • Medical Science
    • Pathology
    • Developmental Biology

    Background:

    • Sirenomelia, a rare congenital anomaly, presents with fusion of the lower limbs.
    • Nephroblastoma (Wilms tumor) is a pediatric kidney cancer.
    • This case involves a complex combination of sirenomelia and nephroblastoma, necessitating detailed examination.

    Purpose of the Study:

    • To report and analyze an autopsy case of sirenomelia with co-occurring nephroblastoma.
    • To document the extensive range of associated congenital anomalies in this specific case.
    • To classify the malformation as sympus monopus based on observed features.

    Main Methods:

    • Autopsy examination of a deceased fetus.
    • Detailed gross pathological examination of all organ systems.
    • Documentation of all identified congenital anomalies.

    Main Results:

    • The autopsy revealed sirenomelia with sympus monopus, characterized by fused lower limbs and a single appendage.
    • A significant finding was the presence of a nephroblastoma within the kidney.
    • Numerous other anomalies were noted, including left renal agenesis, absent external genitalia, imperforate anus, redundant skin, two umbilical vessels, absent great omentum, and patent ductus arteriosus.

    Conclusions:

    • This case represents a rare instance of sirenomelia coexisting with nephroblastoma.
    • The multiplicity of anomalies underscores the complex and severe nature of developmental disruptions in sirenomelia.
    • The findings contribute to the understanding of rare congenital malformation syndromes.

    Related Experiment Videos