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Related Experiment Videos

Intravascular two-dimensional tissue strain imaging.

Yoshifumi Saijo1, Akira Tanaka, Takahiro Iwamoto

  • 1Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Seiryomachi, Aoba-ku, Sendai, Japan. saijo@idac.tohoku.ac.jp <saijo@idac.tohoku.ac.jp>

Ultrasonics
|July 29, 2006
PubMed
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This study introduces a novel intravascular tissue velocity imaging technique to quantify atherosclerosis plaque characteristics. The method correlates tissue strain patterns with plaque composition, identifying vulnerable plaques in clinical settings.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Imaging
  • Medical Physics

Background:

  • Precise quantitative imaging of tissue elasticity is crucial for clinical diagnosis.
  • Atherosclerosis characterization requires advanced imaging modalities.
  • Intravascular ultrasound (IVUS) is a key tool in coronary interventions.

Purpose of the Study:

  • To develop and validate a 2D intravascular tissue velocity imaging method for quantitative assessment of tissue elasticity in atherosclerosis.
  • To correlate ultrasonic characteristics of atherosclerotic plaques with their histological composition.
  • To identify vulnerable plaques using non-invasive imaging techniques.

Main Methods:

  • Digitization of radio-frequency (RF) signals from a clinical IVUS apparatus at 500 MSa/s.

Related Experiment Videos

  • Calculation of correlation coefficients and correction for rotational disuniformity between consecutive frames.
  • Application of template matching for ROI displacement and velocity calculation, defining 2D tissue velocity with >=0.7 correlation.
  • Histological analysis of excised atherosclerotic plaques using Elastica-Masson's trichrome and CD68 immunochemical staining.

    • Main Results:

    • IVUS studies were conducted during directional coronary atherectomy (DCA) procedures in eleven cases.
    • Homogeneous 2D strain patterns correlated with collagen-dominant fibrosis.
    • Complex vector patterns in lesions indicated the presence of CD68 positive cells and degenerated collagen fibers, characteristic of vulnerable plaques.

    Conclusions:

    • The developed 2D intravascular tissue velocity imaging technique enables quantitative assessment of tissue elasticity in atherosclerotic plaques.
    • This imaging modality can differentiate plaque composition, distinguishing between stable fibrotic plaques and vulnerable plaques.
    • The findings suggest potential for improved clinical risk stratification and treatment guidance in patients with atherosclerosis.