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Updated: Aug 6, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Synthesis, spectroscopic characterization and biological analysis of a new palladium(II) complex with methionine
Pedro P Corbi1, Flávia Cagnin, Lilian P B Sabeh
1Departamento de Química Geral e Inorgânica, Instituto de Química, UNESP, Rua Prof. Francisco Degni s/n, CP 355, CEP 14801-970 Araraquara, SP, Brazil. pedrocorbi@yahoo.com
Abstract:
A new palladium(II) complex with methionine sulfoxide was synthesized and characterized by a set of chemical and spectroscopic techniques. Elemental and mass spectrometry analyses of the solid complex fit to the composition [Pd(C5H10NO3S)2].H2O. 13C NMR, [1H-15N] NMR and infrared spectra indicate coordination of the amino acid to Pd(II) through the carboxylate and amino groups in a square planar geometry. The complex is soluble in water. Biological activity was evaluated by cytotoxic analysis using HeLa cells. Determination of cell death was assessed using a tetrazolium salt colorimetric assay, which reflects the cells viability. After incubation for 48 h, 20% of cell death was achieved at a concentration of 200 micromol L-1 of the complex.
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