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Clinicians can help their patients control postprandial hyperglycemia as a means of reducing cardiovascular risk
1General Clinical Research Center, University of Rochester, 601 Elmwood Avenue, Box MED/CRC, Rochester, NY 14642, USA. johngerich@compuserve.com
Insights
Diabetes patients face high cardiovascular disease risk. Controlling postprandial hyperglycemia, or high blood sugar after meals, is crucial for reducing this risk, even with normal fasting glucose levels.
Area of Science:
- Endocrinology
- Cardiology
- Metabolic Syndrome
Background:
- Cardiovascular disease (CVD) is the primary cause of death in diabetic patients.
- Diabetes is now considered a CVD risk factor equivalent to hyperlipidemia, hypertension, and smoking.
- Glycemic control, indicated by HbA1c levels, is essential for managing diabetes and its complications.
Observation:
- Recent research highlights postprandial hyperglycemia as a greater CVD risk than elevated fasting plasma glucose.
- Clinicians must recognize that elevated HbA1c can result from both fasting and postprandial hyperglycemia.
- This is critical for patients with suboptimal HbA1c despite normal fasting glucose readings.
Findings:
- Postprandial hyperglycemia significantly contributes to cardiovascular disease risk in diabetic individuals.
- Elevated blood glucose levels after meals are an independent risk factor for CVD.
- Targeting postprandial glucose is essential for comprehensive diabetes management and CVD prevention.
Implications:
- Clinicians should consider postprandial glucose monitoring and management strategies for diabetic patients.
- Controlling postprandial hyperglycemia may reduce the incidence of cardiovascular events in diabetes.
- Patient education on self-monitoring and managing postprandial glucose levels is vital for improving outcomes.
Abstract:
Cardiovascular disease is the leading cause of morbidity and mortality among patients with diabetes. Having diabetes is now recognized as conferring the same risk for cardiovascular disease as hyperlipidemia, hypertension, and smoking. HbA1c levels are the primary indicator of diabetes control and overall glycemic exposure. And recent research has pointed to postprandial hyperglycemia as conferring a greater risk of cardiovascular disease than elevated fasting plasma glucose levels. Unfortunately, clinicians sometimes forget that elevated HbA1c levels can arise from both fasting hyperglycemia and postprandial hyperglycemia. This is particularly important to remember when treating patients whose HbA1c levels may be higher than the desired target while fasting plasma glucose test results are within reference range. This article reviews the evidence supporting the view that postprandial hyperglycemia is a risk factor for cardiovascular disease and therefore should be controlled. Case studies are presented to aid clinicians in helping patients learn how to measure and control their postprandial glucose levels.
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