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Updated: Aug 6, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Low birthweight and asthma among young urban children
Lenna Nepomnyaschy1, Nancy E Reichman
1Columbia University School of Social Work, New York, NY 10027, USA. ln77@columbia.edu
Insights
Low birthweight significantly increases the risk of early childhood asthma, even after accounting for many individual and neighborhood factors. This persistent association highlights the need for further research into underlying causes.
Area of Science:
- Pediatric Health
- Environmental Epidemiology
- Public Health
Background:
- Low birthweight is a known risk factor for various health issues.
- Early childhood asthma prevalence is a significant public health concern.
- Understanding the interplay between birthweight and environmental factors is crucial for prevention.
Purpose of the Study:
- To determine if individual and neighborhood factors mediate the association between low birthweight and early childhood asthma.
- To identify specific demographic, socioeconomic, medical, behavioral, and neighborhood characteristics that influence this relationship.
- To explore the independent impact of neighborhood housing characteristics on childhood asthma development.
Main Methods:
- Utilized a population-based sample of 1803 children born in large US cities (1998-2000).
- Employed multilevel models to analyze associations between low birthweight and asthma diagnosis by age 3.
- Controlled for a comprehensive set of covariates including prenatal risks, demographics, socioeconomic status, and neighborhood characteristics.
Main Results:
- Children with low birthweight were twice as likely to be diagnosed with asthma by age 3 (34% vs 18%).
- The adjusted odds ratio for asthma in low birthweight children remained significant (OR=2.36, P<.001), similar to the unadjusted odds ratio (OR=2.48, P<.001).
- Higher rates of renter-occupied housing and vacancies at the census tract level independently predicted childhood asthma.
Conclusions:
- The strong association between low birthweight and early childhood asthma is not substantially explained by the assessed individual or neighborhood factors.
- Neighborhood housing characteristics emerged as significant independent predictors of childhood asthma.
- Further investigation into the specific mechanisms linking neighborhood housing conditions and early childhood asthma is warranted.
Objectives:
We assessed whether the association between low birthweight and early childhood asthma can be explained by an extensive set of individual- and neighborhood-level measures.
Methods:
A population-based sample of children born in large US cities during 1998-2000 was followed from birth to age 3 years (N=1803). Associations between low birthweight and asthma diagnosis at age 3 years were estimated using multilevel models. Prenatal medical risk factors and behaviors, demographic and socioeconomic characteristics, and neighborhood characteristics were controlled.
Results:
Low-birthweight children were twice as likely as normal birthweight children to have an asthma diagnosis (34% vs 18%). The fully adjusted association (OR= 2.36; P<.001) was very similar to the unadjusted association (OR= 2.48; P<.001). Rates of renter-occupied housing and vacancies at the census tract-level were strong independent predictors of childhood asthma.
Conclusions:
Very little of the association between low birthweight and asthma at age 3 can be explained by an extensive set of demographic, socioeconomic, medical, behavioral, and neighborhood characteristics. Associations between neighborhood housing characteristics and asthma diagnosis in early childhood need to be further explored.
Related Concept Videos
Asthma-I: Introduction
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Asthma III: Clinical Manifestations
Asthma-III: Symptoms and Complications
Classification of Asthma
Breathing
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
