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Treatment of anthracycline extravasation with dexrazoxane -- clinical experience
Annette Frost1, Daniela Gmehling, Marc Azemar
1Tumor Biology Center at the Albert Ludwigs University, Freiburg i.Br., Germany.
Background:
Accidental extravasation is a severe complication when administering anthracyclines. We describe 3 cases of extravasation with 3 different anthracyclines.
Patients And Methods:
One patient came from another hospital for a second opinion after an epirubicin extravasation. Only surgical debridement of the necrotic tissue was possible. The other two extravasations occurred during treatment with doxorubicin and doxorubicin- EMCH, respectively, in our department. Both patients were treated with dexrazoxane within 6 h of the event.
Results:
The 2 patients treated with dexrazoxane recovered completely without any sequelae.
Conclusions:
Treatment of antracycline extravasation with dexrazoxane is potentially useful and safe.
