Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does autophagy contribute to cell death?

Jayanta Debnath1, Eric H Baehrecke, Guido Kroemer

  • 1Department of Pathology, University of California San Francisco, San Francisco, California, USA. jdebnat@itsa.ucsf.edu

Autophagy
|July 29, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The pyruvate transporter hermes regulates autophagy and health by modulating ROS production.

Cell reports·2026
Same author

Cholesterol transfer proteins promote Atg-independent ER clearance by lysosomes.

Cell reports·2026
Same author

The conserved outer mitochondrial membrane protein Mtch regulates mitophagy during Drosophila intestinal development.

PLoS biology·2026
Same author

Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration.

Nature structural & molecular biology·2025
Same author

Atg9 is a conserved regulator of lysosome repair.

The Journal of cell biology·2025
Same author

VPS13D mutations affect mitochondrial homeostasis and locomotion in Caenorhabditis elegans.

G3 (Bethesda, Md.)·2025

Autophagy, a cellular recycling process, plays a controversial role in cell death. Recent studies using autophagy (atg) gene loss-of-function models investigate its contribution to cell survival and death.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Autophagy is a conserved catabolic process involving cytoplasmic sequestration into autophagosomes for lysosomal degradation.
  • It acts as a survival mechanism during starvation but is also observed in dying cells, leading to debate about its role in programmed cell death.

Purpose of the Study:

  • To review evidence for and against autophagic cell death.
  • To discuss the role of autophagic degradation in dying cells.
  • To identify key areas for future research on autophagy's function in cell fate.

Main Methods:

  • Review of recent loss-of-function studies of autophagy (atg) genes.
  • Analysis of experimental evidence regarding autophagy's role in cell death and survival.

Related Experiment Videos

Main Results:

  • Emerging evidence from atg gene studies provides insights into autophagy's dual role in cell survival and death.
  • The precise contribution of autophagy to cell death remains a subject of ongoing investigation and controversy.

Conclusions:

  • Autophagy's function in cell death is complex and context-dependent.
  • Further research is needed to elucidate the mechanisms by which autophagic degradation influences cell fate decisions.