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Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages
Published on: February 22, 2017
Multiple pulmonary abscesses caused by Legionella pneumophila infection in an infant with croup
Catherine Myers1, Regula Corbelli, Jacques Schrenzel
1Hôpitaux Universitaires de Genève, Department of Pediatrics. catherine.myers@hcuge.ch
Insights
Legionella pneumophila infections are rare in children. Prolonged corticosteroid use for severe croup in an infant led to multiple lung abscesses, highlighting the need for caution with immunosuppression.
Area of Science:
- Pediatric infectious diseases
- Pulmonology
- Immunology
Background:
- Legionella infections are typically rare in pediatric populations.
- Severe croup often requires intensive management, including potential immunosuppressive therapies.
Observation:
- An infant with severe croup received prolonged high-dose corticosteroid treatment.
- The infant subsequently developed multiple pulmonary abscesses.
Findings:
- The pulmonary abscesses were diagnosed as Legionella pneumophila pneumonia.
- Immunosuppression due to corticosteroids was not initially considered, delaying diagnosis.
Implications:
- This case underscores the importance of considering Legionella in children with respiratory infections, especially those on prolonged corticosteroid therapy.
- Clinicians should exercise caution when administering high-dose corticosteroids to pediatric patients with respiratory conditions due to increased infection risk.
Abstract:
Legionella infections are uncommon in childhood. We report the case of an infant who developed multiple pulmonary abscesses caused by Legionella pneumophila after receiving prolonged corticosteroid treatment of severe croup. Diagnosis was not suspected because immunosuppression was not initially considered. Caution should be used when prolonging high-dose corticosteroids in children with respiratory diseases.
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