[Actual treatment options of twin-to-twin transfusion syndrome]
Bartosz Czuba1, Agata Włoch, Dariusz Borowski
1Oddział Kliniczny Połoinictwa i Ginekologii w Rudzie Slaskiej, Katedry Zdrowia Kobiety, Slaskiej Akademii Medycznej w Katowicach.
Abstract:
Twin-to-twin transfusion syndrome -TTTS is observed in 10-15% of monochorionic twin pregnancies. The pathogenesis of the syndrome is still unknown, and the mortality reaches 80-90% if not treated. There are two invasive treatment options of TTTS: Fetoscopic laser coagulation of the placental anastomoses and serial amniodrainages. Endoscopic laser coagulation of anastomoses is a more effective first-line treatment than serial amnioreduction for severe TTTS. The rate of major neurologic complications is higher in amnioreduction group, than in Fetoscopic group.
Insights
Twin-to-twin transfusion syndrome (TTTS) affects monochorionic twins. Fetoscopic laser coagulation is more effective and has fewer neurologic complications than serial amniodrainage for severe TTTS.
Area of Science:
- Perinatology
- Maternal-Fetal Medicine
- Surgical Innovation
Context:
- Twin-to-twin transfusion syndrome (TTTS) affects 10-15% of monochorionic twin pregnancies.
- Untreated TTTS has a high mortality rate of 80-90%.
- Current invasive treatments include fetoscopic laser coagulation and serial amniodrainage.
Purpose:
- To compare the efficacy and outcomes of fetoscopic laser coagulation versus serial amniodrainage for severe TTTS.
Summary:
- Fetoscopic laser coagulation of placental anastomoses is a more effective first-line treatment for severe TTTS compared to serial amniodrainage.
- The rate of major neurologic complications is significantly higher in the amniodrainage group than in the fetoscopic laser coagulation group.
Impact:
- Fetoscopic laser coagulation offers a superior treatment option for severe TTTS, improving survival rates and reducing neurological morbidity.
- This finding supports laser coagulation as the preferred first-line invasive therapy for managing severe TTTS.
Related Concept Videos
Kidney Transplant II: Surgical Procedure
Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction

