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Updated: Aug 6, 2026
Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells
Published on: February 22, 2020
[Natural killer-like T-cell lymphoma/leukemia--a case report and literature review]
Feng-kui Zhang1, Hui-jun Wang, Yu-hong Wu
1Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China.
Objective:
To identify the clinical and pathological features of natural killer-like T-cell lymphoma/leukemia.
Methods:
The characteristics of natural killer-like T-cell lymphoma/leukemia was discussed with report a new case and review of literatures.
Results:
A 16-year-old girl was referred to our hospital because of fever and disseminated cutaneous herpes and ulcer. Atypical lymphoid cells surrounded the dermal vessels with a CD3(+), CD8(+), CD4(-), CD5(-), CD10(-), CD19(-), CD57(-), CD56(+), perforin(+), granzyme B(+) immunophenotype and rearranged T-cell receptor-gamma gene implicated natural killer-like T cell origin. She was treated with prednisone and for several months. Then the patient developed progressive spleen enlargement with overt leukemia, which led to her eventual death.
Conclusions:
Natural killer-like T-cell lymphoma/leukemia is a rare disease with distinctive clinical, histopathologic, and immuno phenotypic characteristics. Current treatment modalities are ineffective for most of the patients.
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