Location of brain rhythms and their modulation by preparatory attention estimated by current density

To test the hypothesis that there is a functional modulation of conventional EEG bands associated with preparatory attention, putative changes in the spontaneous brain rhythms and their associated cerebral sources were addressed. The goals of the present report were, first, to find the brain areas with maximal rhythmic activity before warning and imperative stimuli in a classic contingent negative variation (CNV) paradigm, and, second, to study the modulation of the EEG rhythms of these areas during the preparatory attention interval which precedes the S2 (imperative) stimulus. Trial by trial LORETA analysis found similar brain rhythm generators during both pre-S1 and pre-S2 intervals. Each theta, alpha and beta traditional EEG rhythm originates in several anatomically distinct brain structures. Preparatory attention is associated with a decrease in power in alpha (right and left occipital and temporal areas) and low-beta (left frontal, bilateral occipital and middle frontal areas) EEG bands. In these structures power changes associated with preparatory attention modulated either a dominant or a non-dominant oscillatory band, suggesting that non-dominant rhythms of a cerebral area have some functional relevance. Our results imply distributed regional sources for brain rhythms and support the view that during preparatory attention there is a modulation of the brain sources generating alpha and beta brain rhythms. Moreover, the proposed combined approach makes it possible to explore the definition of a given brain area not only anatomically, but also by the frequency content and the functional reactivity of the electrical rhythms that it generates.