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Published on: July 5, 2017
Effects of sex and age on strength-duration properties
Deniz Yerdelen1, Hilmi Uysal, Filiz Koc
1Department of Neurology, Cukurova University Medical School, Adana, Turkey. wvdeniz@superonline.com
Objective:
To evaluate the possible effects of sex and age on strength-duration time constant (SDTC).
Methods:
The SDTC of 126 healthy volunteers was measured following stimulation of right median nerve at the wrist. Variations in values were evaluated according to sex and age.
Results:
The SDTC was 438.6+/-114.5 micros in women and 396.2+/-90.3 in men (P=.023). In men, as age increased, so did SDTC. However, this was not true in women. Comparing the values of women and men, aged below 40, demonstrated a difference in excitability, confined to younger patients.
Conclusions:
As SDTC depends on the biophysical properties of the axonal membrane and can provide some information about Na(+) channel function, these data raise the possibility of a difference in Na(+) channel function between men and women and a difference in the conductance with age.
Significance:
The age- and sex-related differences shown in this study suggest a possible biochemical or hormonal influence on axonal excitability.
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