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Published on: January 28, 2020

Metabolic syndrome, C-reactive protein, and prognosis in patients with established coronary artery disease

David Aguilar1, Marian R Fisher, Christopher M O'Connor

  • 1Cardiology Division, Baylor College of Medicine, Houston, TX 77030, USA. daguilar@bcm.edu

American Heart Journal
|August 1, 2006
PubMed

Insights

Metabolic syndrome and high-sensitivity C-reactive protein (hs-CRP) increase cardiovascular risk in stable coronary artery disease patients. These factors are linked to adverse outcomes, highlighting their prognostic significance.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Inflammation Markers

Background:

  • Prognostic significance of metabolic syndrome and hs-CRP in stable coronary artery disease (CAD) is not well-established.
  • WIZARD study investigated antibiotic therapy effects on CAD events in patients with known Chlamydia pneumoniae exposure.

Purpose of the Study:

  • To evaluate the prognostic value of metabolic syndrome and hs-CRP in patients with stable coronary artery disease.
  • To determine the association between these factors and adverse cardiovascular outcomes.

Main Methods:

  • Analysis of baseline metabolic risk factors from 3319 patients in the WIZARD study (1997-1998).
  • Primary outcome: composite of death, myocardial infarction, revascularization, or angina hospitalization.
  • Multivariable analysis adjusted for age and sex.

Main Results:

  • Metabolic syndrome (unadjusted HR 1.40, adjusted HR 1.33) and hs-CRP (unadjusted HR 1.60, adjusted HR 1.52) were associated with increased risk of the primary outcome.
  • 825 patients experienced the primary outcome during a mean follow-up of 37 months.

Conclusions:

  • Metabolic syndrome and elevated hs-CRP levels are independently associated with increased risk of adverse cardiovascular outcomes in stable CAD.
  • These findings underscore the importance of managing metabolic risk factors and inflammation in CAD patients.
Abstract

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