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The negative inotropic effect of diazepam in rat right ventricular strips
1Departamento de Fisiología y Farmacología, Facultad de Medicina, Espinardo-Murcia, Spain.
The Journal of Pharmacy and Pharmacology
|December 1, 1991
Abstract:
The effect of diazepam on cardiac contractility was investigated in electrically-driven right ventricular strips of the rat. Diazepam produced a concentration-dependent negative inotropic effect which was antagonized by either flumazenil, a benzodiazepine central-type receptor antagonist, or PK 11195, a benzodiazepine peripheral type receptor antagonist. The results suggest that the inhibitory effect of diazepam on cardiac contractility in the rat is mediated by both central and peripheral benzodiazepine receptors.