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A novel bradykinin antagonist with improved properties
1Department of Medicine, Thorndike Memorial Laboratory, Boston City Hospital, Massachusetts.
The Journal of Pharmacy and Pharmacology
|December 1, 1991
Abstract:
Acylation of the N-terminus of [D-Arg0, Hyp3, Thi5,8, D-Phe7] bradykinin with 1-adamantanecarboxylic acid results in an analogue with enhanced potency of at least 33-fold. The new antagonist has potential as a pharmacological tool in the investigation of the role of endogenous bradykinin in cardiovascular regulation.