Related Experiment Video
Updated: Aug 6, 2026

05:16
Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
Published on: October 27, 2023
Chondroid metaplasia in inflamed pulp tissue: a case report
Luciano Giardino1, Enrico Savoldi, Francesco Pontieri
1Department of Periodontology, Dental School of Brescia, Italy. lucianogiardino@libero.it
Summary
This case report details chondroid metaplasia in dental pulp, a rare finding possibly linked to tissue repair following carious lesions. It highlights pulp tissue
Area of Science:
- Endodontics
- Oral Pathology
- Dental Histology
Background:
- Dental caries can lead to irreversible pulpitis, a common endodontic concern.
- Pulp tissue's response to injury and infection is complex and can involve metaplastic changes.
Observation:
- A 45-year-old female presented with irreversible pulpitis in a decayed third molar.
- Histological examination revealed chondroid metaplasia within the dental pulp tissue.
Findings:
- The affected pulp horn showed colliquative necrosis with surrounding inflammation.
- Chondroid tissue formation was observed, indicative of a metaplastic response to injury.
Implications:
- This is potentially the first reported case of chondroid metaplasia in dental pulp.
- Suggests pulp tissue may attempt repair via metaplasia, deviating from normal differentiation.
- Highlights the adaptive capacity of dental pulp to environmental stimuli.
Related Concept Videos
Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Bowel Disease II: Crohn's Disease
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Cellular Adaptation IV: Dysplasia and Metaplasia
DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...