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Karsten Schnatbaum1, Elsa Locardi, Dirk Scharn

  • 1Jerini AG, Invalidenstrasse 130, 10115 Berlin, Germany. schnatbaum@jerini.de

Bioorganic & Medicinal Chemistry Letters
|August 1, 2006
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Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
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